Modern Care Journal

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The Prevalence of Hepatitis B and C Virus Co-Infection Among a Group of Iranian Population

Sanaz Ahmadi-Ghezeldasht 1 , Mohammad Reza Hedayati-Moghaddam 1 , * and Mohammad Mehdi Akbarin 1
Authors Information
1 Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, IR Iran
Article information
  • Modern Care Journal: April 2017, 14 (2); e64808
  • Published Online: April 30, 2017
  • Article Type: Research Article
  • Received: January 30, 2017
  • Accepted: March 25, 2017
  • DOI: 10.5812/modernc.64808

To Cite: Ahmadi-Ghezeldasht S, Hedayati-Moghaddam M R, Akbarin M M. The Prevalence of Hepatitis B and C Virus Co-Infection Among a Group of Iranian Population, Mod Care J. 2017 ; 14(2):e64808. doi: 10.5812/modernc.64808.

Copyright © 2017, Modern Care Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Hassanjani-Roshan M-R, Taheri H. Frequency of chronic active hepatitis in asymptomatic HBV carriers in Babol, Iran. Arch Iran Med. 2002;5(2):90-100.
  • 2. Shepard CW, Finelli L, Alter MJ. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005;5(9):558-67.
  • 3. Brass V, Moradpour D. New insights into hepatitis B and C virus co-infection. J Hepatol. 2009;51(3):423-5. doi: 10.1016/j.jhep.2009.06.003. [PubMed: 19596479].
  • 4. Liaw YF. Hepatitis C virus superinfection in patients with chronic hepatitis B virus infection. J Gastroenterol. 2002;37 Suppl 13:65-8. [PubMed: 12109669].
  • 5. Genesca J, Esteban JI, Alter HJ. Blood-borne non-A, non-B hepatitis: hepatitis C. Semin Liver Dis. 1991;11(2):147-64. doi: 10.1055/s-2008-1040432. [PubMed: 1653459].
  • 6. Chu C-M, Sheen I-S, Liaw Y-F. The role of hepatitis C virus in fulminant viral hepatitis in an area with endemic hepatitis A and B. Gastroenterol. 1994;107(1):189-95.
  • 7. Jamma S, Hussain G, Lau DT. Current Concepts of HBV/HCV Coinfection: Coexistence, but Not Necessarily in Harmony. Curr Hepat Rep. 2010;9(4):260-9. doi: 10.1007/s11901-010-0060-4. [PubMed: 21258658].
  • 8. Liaw Y-F. Role of hepatitis C virus in dual and triple hepatitis virus infection. Hepatol. 1995;22(4):1101-8.
  • 9. Fathimoghaddam F, Hedayati-Moghaddam MR, Bidkhori HR, Ahmadi S, Sima HR. The prevalence of hepatitis B antigen-positivity in the general population of Mashhad, Iran. Hepat Mon. 2011;11(5):346-50. [PubMed: 22087159].
  • 10. Ghezeldasht SA, Hedayati-Moghaddam MR, Shamsian K, Fathimoghadam F, Bidkhori HR, Rezaee SA. Prevalence of Hepatitis C Virus Infection in General Population of Mashhad, Northeastern Iran. Iran J Pub Health. 2017;46(3):408-13.
  • 11. Saravanan S, Velu V, Nandakumar S, Madhavan V, Shanmugasundaram U, Murugavel KG, et al. Hepatitis B virus and hepatitis C virus dual infection among patients with chronic liver disease. J Microbiol Immunol Infect. 2009;42(2):122-8. [PubMed: 19597643].
  • 12. Crespo J, Lozano J, De la Cruz F, Rodrigo L, Rodriguez M, San Miguel G. Prevalence and significance of hepatitis C viremia in chronic active hepatitis B. Am J Gastroenterol. 1994;89(8).
  • 13. Pontisso P, Ruvoletto MG, Fattovich G, Chemello L, Gallorini A, Ruol A. Clinical and virological profiles in patients with multiple hepatitis virus infections. Gastroenterol. 1993;105(5):1529-33.
  • 14. Liang TJ, Bodenheimer HC, Yankee R, Brown NV, Chang K, Huang J. Presence of hepatitis B and C viral genomes in US blood donors as detected by polymerase chain reaction amplification. J Medvirol. 1994;42(2):151-7.
  • 15. Liu CJ, Liou JM, Chen DS, Chen PJ. Natural course and treatment of dual hepatitis B virus and hepatitis C virus infections. J Formos Med Assoc. 2005;104(11):783-91. [PubMed: 16496056].
  • 16. Reimer J, Lorenzen J, Baetz B, Fischer B, Rehm J, Haasen C, et al. Multiple viral hepatitis in injection drug users and associated risk factors. J Gastroenterol Hepatol. 2007;22(1):80-5. doi: 10.1111/j.1440-1746.2006.04358.x. [PubMed: 17201886].
  • 17. Roshandel G, Semnani S, Abdolahi N, Besharat S, Kashtkar AA, Joshaghani HR. The prevalence of Co-infection with HCV and HDV in HBV infected patients in Golestan province of Iran [In Persian]. J Gorgan Univ Med Sci. 2008;9(4):61-5.
  • 18. Fong TL, Di Bisceglie AM, Waggoner JG, Banks SM, Hoofnagle JH. The significance of antibody to hepatitis C virus in patients with chronic hepatitis B. Hepatology. 1991;14(1):64-7. [PubMed: 1648540].
  • 19. Fattovich G, Tagger A, Brollo L, Pontisso P, Realdi G, Ferroni P, et al. Liver disease in anti-HBe positive chronic HBsAg carriers and hepatitis C virus. Lancet. 1989;334(8666):797-8.
  • 20. Barros H, Miranda HP, Silvestre F. Hepatitis C virus antibodies in asymptomatic chronic carriers of hepatitis B surface antigen. Acta Med Port. 1994;7:30-4.
  • 21. Bruix J, Calvet X, Costa J, Ventura M, Bruguera M, Castillo R, et al. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 1989;334(8670):1004-6.
  • 22. Simonetti RG, Camma C, Fiorello F, Cottone M, Rapicetta M, Marino L, et al. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. A case-control study. Ann Intern Med. 1992;116(2):97-102. [PubMed: 1309286].
  • 23. Liaw YF, Chen YC, Sheen IS, Chien RN, Yeh CT, Chu CM. Impact of acute hepatitis C virus superinfection in patients with chronic hepatitis B virus infection. Gastroenterol. 2004;126(4):1024-9.
  • 24. Osella AR, Misciagna G, Guerra VM, Chiloiro M, Cuppone R, Cavallini A, et al. Hepatitis C virus (HCV) infection and liver-related mortality: a population-based cohort study in southern Italy. The Association for the Study of Liver Disease in Puglia. Int J Epidemiol. 2000;29(5):922-7. [PubMed: 11034979].
  • 25. Marcellin P. Hepatitis B and hepatitis C in 2009. Liver Int. 2009;29 Suppl 1:1-8. doi: 10.1111/j.1478-3231.2008.01947.x. [PubMed: 19207959].
  • 26. Fattovich G, Tagger A, Brollo L, Giustina G, Pontisso P, Realdi G, et al. Hepatitis C virus infection in chronic hepatitis B virus carriers. J Infect Diseas. 1991;163(2):400-2.
  • 27. Liaw YF, Lin SM, Sheen IS, Chu CM. Acute hepatitis C virus superinfection followed by spontaneous HBeAg seroconversion and HBsAg elimination. Infection. 1991;19(4):250-1. [PubMed: 1917039].
  • 28. Sheen IS, Liaw YF, Deng-Yn , Chu CM.Lin. Role of hepatitis C and delta viruses in the termination of chronic hepatitis B surface antigen carrier state: a multivariate analysis in a longitudinal follow-up study. J Infect Diseas. 1994;170(2):358-61.
  • 29. Sato S, Fujiyama S, Tanaka M, Yamasaki K, Kuramoto I, Kawano S. Coinfection of hepatitis C virus in patients with chronic hepatitis B infection. J Hepatol. 1994;21(2):159-66.
  • 30. Zarski JP, Bohn B, Bastie A, Pawlotsky JM, Baud M, Bost-Bezeaux F, et al. Characteristics of patients with dual infection by hepatitis B and C viruses. J Hepatol. 1998;28(1):27-33.
  • 31. Ohkawa K, Hayashi N, Yuki N, Masuzawa M, Kato M, Yamamoto K, et al. Long-term follow-up of hepatitis B virus and hepatitis C virus replicative levels in chronic hepatitis patients coinfected with both viruses. J Med Virol. 1995;46(3):258-64. [PubMed: 7561800].
  • 32. Sheen IS, Liaw YF, Chu CM, Pao CC. Role of hepatitis C virus infection in spontaneous hepatitis B surface antigen clearance during chronic hepatitis B virus infection. J Infect Dis. 1992;165(5):831-4. [PubMed: 1314869].
  • 33. Raimondo G, Brunetto MR, Pontisso P, Smedile A, Maina AM, Saitta C, et al. Longitudinal evaluation reveals a complex spectrum of virological profiles in hepatitis B virus/hepatitis C virus-coinfected patients. Hepatology. 2006;43(1):100-7. doi: 10.1002/hep.20944. [PubMed: 16323213].
  • 34. Liaw YF. Concurrent hepatitis B and C virus infection: Is hepatitis C virus stronger?. J Gastroenterol Hepatol. 2001;16(6):597-8. [PubMed: 11422609].
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